No — there is no sleeper train to Manchester. Britain's two overnight sleepers run London–Scotland (Caledonian Sleeper) and London–Penzance (Night Riviera), and neither serves the city. For London–Manchester, fast daytime Avanti West Coast trains from Euston reach Manchester Piccadilly in around two hours ten, so an overnight would be slower and pointless over that distance. Where Manchester is genuinely useful is as a northern rail hub: if you're heading to the Scottish Highlands from the North West, you take a daytime service and connect — but the sleeper itself starts from London Euston, not Manchester, so there's no berth to book from Piccadilly. There's no plan to add a Manchester sleeper, and the geography is against it; sleepers only pay off on the long hauls to the Highlands or the far South West, where you sleep through the miles and save a hotel night. If you specifically want the overnight-train experience, the Caledonian Sleeper north or the Night Riviera south-west are your only UK options, which from Manchester means travelling down to London first or joining a Scotland-bound daytime train. Check current Avanti and connecting timetables when you plan, as services vary between periods.
Sources: seat61.com
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